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Image Search Results
Journal: Frontiers in Cellular and Infection Microbiology
Article Title: Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety
doi: 10.3389/fcimb.2026.1734356
Figure Lengend Snippet: Network pharmacology and molecular docking elucidate potential mechanisms of HYP in UC treatment. (A) Venn diagram of HYP and UC target genes. (B) PPI network of common targets. (C) KEGG pathway analysis. (D) The top 20 gene targets ranked by degree value. Molecular docking binding modes and affinities of HYP with (E) MAPK3, (F) AKT1, and (G) NFκB1. (H) Protein expression levels of p38MAPK, p-p38MAPK, AKT, p-AKT, NF-κB p65, and p-NF-κB p65 in the colon tissues.
Article Snippet: The following antibodies were used in this study: anti-ZO-1 antibody (AF5145, Affinity), anti-mucin-2 antibody (GB11344, Serbicebio), anti-BDNF antibody (GB11559, Serbicebio), anti-GFAP antibody (GB11096, Serbicebio), anti-Iba-1 antibody ( GB154490 , Serbicebio),
Techniques: Binding Assay, Expressing
Journal: Frontiers in Cellular and Infection Microbiology
Article Title: Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety
doi: 10.3389/fcimb.2026.1734356
Figure Lengend Snippet: Schematic of the mechanism by which HYP ameliorates DSS-induced UC and associated anxiety-like behaviors. HYP alleviates UC and comorbid anxiety through gut microbiota-dependent mechanisms. It remodels the gut microbial community, thereby enhancing host arginine metabolism and directly modulating the MAPK/PI3K-Akt/NF-κB signaling pathways. This integrated action suppresses systemic and neuroinflammation, restores intestinal barrier function, and ultimately ameliorates both colonic pathology and anxiety-like behaviors.
Article Snippet: The following antibodies were used in this study: anti-ZO-1 antibody (AF5145, Affinity), anti-mucin-2 antibody (GB11344, Serbicebio), anti-BDNF antibody (GB11559, Serbicebio), anti-GFAP antibody (GB11096, Serbicebio), anti-Iba-1 antibody ( GB154490 , Serbicebio),
Techniques: Protein-Protein interactions
Journal: Clinical, Cosmetic and Investigational Dermatology
Article Title: A Topical Chinese Herbal Alleviates Psoriasis by Regulating Keratinocytes Pyroptosis Through Inhibition of NLRP3 Inflammasome Activation
doi: 10.2147/CCID.S559712
Figure Lengend Snippet: ( A – C ) mRNA levels of NLRP3, Caspase-1, GSDMD in NHEK cells, n = 3. ( D – I ) Protein levels of NF-κB, P65, NLRP3, caspase-1, GSDMD in NHEK cells, n = 3.*P < 0.05, **P < 0.01, ***P < 0.001 compared with Control; # P < 0.05, ## P < 0.01, ### P < 0.001 compared with Model; & P < 0.05, && P < 0.01, &&& P < 0.001 compared with QS; ^P < 0.05, ^^P < 0.01 compared with Mcc950.
Article Snippet: The sections were then incubated overnight at 4°C with the following primary antibodies:
Techniques: Control